Dr. Jerold Chun, a professor of neuroscience at the Scripps Research Institute in La Jolla, California, together with his colleagues, simulated the bleeding in the brain of mice by injecting LPA. The researchers were under the impression that a fetus’s brain exposure to blood may be triggering hydrocephalus. All of the mice in the study developed hydrocephalus and died two to six weeks after they were born.
The researchers administered a drug to the mice in order to block the binding of the LPA to the brain cells, which successfully prevented the development of hydrocephalus.
James McAllister, the director of basic hydrocephalus research at the University of Utah School of Medicine, says that this study "is an important step forward in understanding the cause. In addition, this study provides new therapeutic opportunities for developing drugs that could help in the clinical management of this serious neurological disorder of newborns.”